Once full results of fat-reducing Kybella and CoolMini are achieved, they will be permanent as long as you maintain a healthy weight. Juvéderm Ultra Plus and Voluma are hyaluronic acid fillers that require a touchup every 6 months to a year. Ultherapy tightens skin by stimulating collagen production, but gravity continues to work against you so that maintenance treatments are needed about every 2 years.