A VI Peel can be performed in a medspa or cosmetic dermatology clinic and can be administered by a licensed nurse, a certified aesthetician or a medical doctor. While older procedures for chemical peels included skin preconditioning, there is no preconditioning needed prior to receiving a VI Peel. The application process can take up to 30 minutes and involves the chemical solution being topically applied to the skin. The peel is then left on the skin for five hours and washed off by the patient at home. Some patients experience light stinging during application, which subsides quickly.

Patients can receive VI Peels repeatedly every two weeks until they receive their desired results; however, most patients need only one initial treatment followed by regular peels three to four times per year for continuing skin renewal and luminosity.